Typhoid Fever by Richard Adler

Author:Richard Adler
Language: eng
Format: epub
Publisher: McFarland & Company, Inc., Publishers
Published: 2016-02-18T00:00:00+00:00

Pfeiffer claimed that the reaction of the serum employed in this manner is so distinctly specific that it may serve for the differential diagnosis of the cholera-vibrion from other vibrions. If a mixture of the cultures of two vibrions is used in this experiment, only that species is destroyed which has been employed to immunize the animal whose serum is introduced with the cultures.10

Pfeiffer and his associate Wilhelm Kolle shortly afterwards applied this phenomenon in their proposal that immune serum could be used in the diagnosis not only of cholera, but also in differentiating typhoid infections from other intestinal infections; in part, these applications confirmed results which Gruber had previously reported.11

The authors [Pfeiffer and Kolle] say that by the aid of the serum of convalescents from typhoid fever, or of animals immunized against typhoid infection, typhoid bacilli can be differentiated from the bacillis coli communis and from other bacteria resembling the typhoid bacillus. This is accomplished by mixing the serum with cultures of the typhoid bacillus and introducing the mixture into the peritoneal cavity of guinea-pigs. A specific reaction appears, which can be followed microscopically. Agglomeration and agglutination of the bacilli occur, followed by deformity and final solution…. The bacteria belonging to the coli group, and all other similar bacteria, are not influenced in this test when the serum of animals immunized to the typhoid bacillus is employed. “This change takes place only with the typhoid bacilli, and is a specific reaction due to the bactericidal reaction of the typhoid serum.”

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